Ketamine for Mental Health: Insights from the Huberman Lab Podcast

This episode dives into how ketamine rewires brain circuits, relieves depression and PTSD, and induces dissociative states. Dr. Andrew Huberman explores ketamine's effects on glutamate and opioid pathways, which influence mood and well-being. Clinical applications include treating major depression, bipolar depression, OCD, and suicidality. The episode also examines the subjective experiences of dissociation and euphoria caused by ketamine, its various administration routes, dosages, and the debated effectiveness of microdosing. Additionally, it addresses the risks of recreational ketamine use, such as “K-holes.” A must-listen for those curious about ketamine's role in mental health, psychiatry, and neuroplasticity.